Effect of Adrenaline, Nor adrenaline, Isopropyl Nor adrenaline and Ephedrine on Tone and Lactic Acid Formation in Bovine Tracheal Muscle

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Abstract
Summary.: The relaxing and the lactic acid forming effects on bovine tracheal muscle of adrenaline, nor adrenaline, isopropyl‐nor adrenaline and ephedrine were compared.All four drugs had both a relaxing and a lactic acid forming effect. The degree of relaxation tended to run parallel with the rise in lactic acid content.Drugs inhibiting glycol sis totally abolished the relaxing effect of all sympathomimetic amines that were studied.The concentrations of l‐adrenaline. l‐nor adrenaline, dl‐isopropyl‐nor adrenaline and 1‐ephedrine producing a maximal relaxing effect had a ratio of 1: 2: 10: 350.

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