The activity of mitochondrial α-glycerophosphate dehydrogenase in the rat nephron following triiodo-L-Thyronine treatment

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Abstract
The effect of triiodo-L-thyronine (T3) treatment (15 μg/100 g body weight daily for 10 days) on the activity of mitochondrial α-glycerophosphate dehydrogenase (GPOX) in different nephron segments of the male rat was investigated by a histochemical staining method. The study showed marked segmental differences regarding the response to T3-treatment: The first two proximal segments were unstained in the control rats andintensely stained following treatment. The third proximal segments, the thick ascending limbs of Henle's loop and the distal convoluted tubules showed a strong or moderate reaction in controls and amoderate increase after T3-treatment. The high activity of collecting ducts in the cordex and outer zone of the medulla in controls wasslightly increased by treatment. Faintly reacting glomeruli and negative thin limbs of Henle's loop and collecting ducts in the inner medulla (papilla) wereunaffected by T3-treatment. The results are discussed in relation to biochemical and physiological data.