Outflow Paths of Cells from the Lymph Node Parenchyma to the Efferent Lymphatics

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Abstract
Observations in the mouse lymph nodes using thin section histology made the authors conclude that the outflow of lymphocytes to the efferent lymphatics is probably a passive desquamation of cells. In the medullary sinuses this outflow seems to be restricted to circumscribed desquamation zones. The authors describe a specific type of structure, ad interim named ‘mud streams’, which probably represents a concentration of outflowing lymphocytes in extended desquamation zones, reaching deep into the parenchyma as temporary first segments of the efferent sinus system. These structures, which are difficult to recognize in routine, thick sections are very spectacular in 1 μ sections, together with the high endothelium venules they decide the specific morphologic pattern of the paracortical area of lymph nodes.

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