In VitroInhibition of [3 H]-Angiotensin II Binding on the Human AT1Receptor by Proanthocyanidins fromGuazuma ulmifoliaBark
- 20 December 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 68 (12) , 1066-1071
- https://doi.org/10.1055/s-2002-36344
Abstract
A bioassay-guided fractionation of the 70 % acetone extract of the bark of Guazuma ulmifolia Lam. on the inhibition of angiotensin II binding to the AT1 receptor led to the isolation and identification of bioactive oligomeric and polymeric proanthocyanidins consisting mainly of (-)-epicatechin units. The displacement of [3 H]-angiotensin II binding was dose-dependent and correlated with the degree of polymerization of the different fractions containing proanthocyanidins. A strong displacement was seen for the residual fraction suggesting that the most active substances corresponding to the highly polymerized proanthocyanidins. Angiotensin II AT1 receptor binding might be considered as a potentially interesting biological activity of proanthocyanidins contributing to the very broad spectrum of biological activities of the condensed tannins.Keywords
This publication has 0 references indexed in Scilit: