STUDIES ON 3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL]-1-(2-CHLOROETHYL)-1-NITROSOUREA HYDROCHLORIDE .2. ANTI-TUMOR ACTIVITY OF 3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-1-(2-CHLOROETHYL)-1-NITROSOUREA HYDROCHLORIDE IN A VARIETY OF EXPERIMENTAL-TUMORS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (4) , 545-548
Abstract
The antitumor activity of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU) against various [transplantable mouse] tumors was examined. The compound was markedly active against myeloid leukemia C1498, plasmacytoma X5563, Ehrlich ascites carcinoma and mammary tumor FM3A43. It was moderately active against mammary tumor MM102 and meningeal sarcoma MS147.