Neuroleptic Action of Clozapine Injected into Various Brain Areas in Rats
- 1 July 1975
- journal article
- Published by S. Karger AG in International Pharmacopsychiatry
- Vol. 10 (2) , 89-93
- https://doi.org/10.1159/000468175
Abstract
Bilateral microinjections of clozapine into the corpus striatum of rats antagonize amphetamine-induced stereotypy, and develops catalepsy. These two neuroleptic effects are not seen after subcutaneous or oral administration of clozapine. The effects were a little weaker than those seen after chlorpromazine. No neuroleptic effects were observed, when placebo was injected intrastriatally, nor when clozapine was injected into the hippocampus or the thalamus.Keywords
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