Bacterial [Cu,Zn]-Cofactored Superoxide Dismutase Protects Opsonized, EncapsulatedNeisseria meningitidisfrom Phagocytosis by Human Monocytes/Macrophages
Open Access
- 1 March 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (3) , 1604-1607
- https://doi.org/10.1128/iai.71.3.1604-1607.2003
Abstract
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.Keywords
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