Unequal α and β Globin mRNA in Reticulocytes of Normal and Mutant f/f Fetal Mice

1 March 1980

journal article
research article
Published by Wiley in British Journal of Haematology

Vol. 44 (3) , 431-439
https://doi.org/10.1111/j.1365-2141.1980.tb05913.x

Abstract

Summary. Messenger RNA (mRNA) was isolated from adult as well as normal and mutant f/f fetal mouse reticulocytes by poly-U affinity chromatography. mRNA from normal adult reticulocytes directed equal synthesis of α and β globin chains in wheat germ cell free translational system. mRNA from either normal or mutant f/f fetal reticulocytes directed 40% more α globin synthesis than β globin synthesis. These observations are suggestive that there is significantly more α mRNA than β mRNA in normal and mutant f/f fetal mouse reticulocytes.

This publication has 23 references indexed in Scilit:

Balanced accumulation of α- and β-globin mRNA in differentiating fetal mouse erythroid cells
FEBS Letters, 1978
Ratios of α-to β-globin mRNA and regulation of globin synthesis in reticulocytes
Nature, 1977
Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia.
Proceedings of the National Academy of Sciences, 1975
Further evidence of a quantitative deficiency of chain-specific globin mRNA in the thalassemia syndromes.
Proceedings of the National Academy of Sciences, 1975
PROTEIN SYNTHESIS BY MEMBRANE-BOUND RETICULOCYTE RIBOSOMES
Annals of the New York Academy of Sciences, 1974
Model for the regulation of mRNA translation applied to haemoglobin synthesis
Nature, 1974
Disturbed haem and globin synthesis in reticulocytes of prenatal flexed-tailed (f/f) anaemic mice
Genetics Research, 1974
Translational Control of Globin Synthesis by Haemin in Xenopus Oocytes
Nature New Biology, 1973
Efficient Translation of Tobacco Mosaic Virus RNA and Rabbit Globin 9S RNA in a Cell-Free System from Commercial Wheat Germ
Proceedings of the National Academy of Sciences, 1973
Membrane-Bound Ribonucleic Acid in Mammalian Erythroid Cells^*
Biochemistry, 1967