Should Levodopa Therapy Be Started Early or Late?

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Abstract
Clinical and experimental evidence suggests that, in Parkinson’s disease, the late-occurring fluctuations in response to levodopa therapy are due to progression of the disease rather than to the therapy. Therefore, treatment with carbidopa/levodopa should be started early, because postponement does not provide patients with added benefits but deprives them of the most satisfying period of the therapeutic response.