Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 ofPlasmodium falciparum
Open Access
- 1 February 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (2) , 1207-1211
- https://doi.org/10.1128/iai.69.2.1207-1211.2001
Abstract
Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed toPlasmodium falciparumrevealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.Keywords
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