Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two
- 1 August 1984
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 144 (8) , 1562-1568
- https://doi.org/10.1001/archinte.144.8.1562
Abstract
In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole or the combination of sulfamethoxazole and trimethoprim and ketoconazole. Both sulfamethoxazole and trimethoprim and the combination of sulfamethoxazole and trimethoprim and ketoconazole substantially reduced the overall incidence of infection consequent to a marked decrease in bacterial infection. Sulfamethoxazole and trimethoprim were associated with an increased rate of fungal infection, while ketoconazole decreased this complication. No form of prophylaxis reduced infectious mortality or increased the complete remission rate. Because of its effect in reducing infectious morbidity, patients with acute leukemia receiving remission induction treatment should be given antibacterial and antifungal prophylaxis.This publication has 5 references indexed in Scilit:
- CO-TRIMOXAZOLE ALONE FOR PREVENTION OF BACTERIAL INFECTION IN PATIENTS WITH ACUTE LEUKAEMIAThe Lancet, 1982
- Prevention of Infection by Trimethoprim-Sulfamethoxazole Plus Amphotericin B in Patients with Acute Nonlymphocytic LeukaemiaAnnals of Internal Medicine, 1981
- Prophylactic Trimethoprim-Sulfamethoxazole During Consolidation Chemotherapy for Acute Leukemia: A Controlled TrialAnnals of Internal Medicine, 1981
- Infection Prevention During Profound GranulocytopeniaAnnals of Internal Medicine, 1980
- A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patientsThe American Journal of Medicine, 1979