EXPERIMENTAL EVALUATION OF CONCENTRATED SOLUTIONS OF IOTHALAMIC ACID DERIVATIVES AS ANGIOGRAPHIC CONTRAST MEDIA

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Abstract
Two new concentrated contrast agents, MP 1005.2 and MP 2032, which are derivatives of iothalamic acid have been tested as angiographic contrast media. The results have been compared to results obtained with hypaque M-90; both of the new media proved to be less neurotoxic and nephrotoxic. Thus, in equivalent solutions iothalamate salts proved to be less toxic than the diatrizoate salts. The intravenous tolerance of these media was far better than with hypaque M-90. MP 2032 is far too viscous for use as a concentrated medium—it may find usefulness as a less concentrated contrast agent. MP 1005.2 is sufficiently impressive to warrant trial as an aortographic medium—especially in thoracic aortography.

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