Radiosensitization ofSerratia marcescensby Cetylpyridinium Chloride

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Abstract
Cetylpyridinium chloride is an effective radiosensitizer of both oxic and anoxic suspensions of S. marcescens in buffer. The related compounds ethylpyridinium bromide and cetyltrimethylammonium chloride exhibited no such radiosensitizing properties at comparable concentrations. The efficiency of cetylpyridinium chloride may be due to the combination of lipid-soluble (cetyl) and electron-affinic (pyridinium) moieties within the same molecule. These may provide for interaction with a membrane-associated target. Cetylpyridinium chloride did not radiosensitize bacteria suspended in nutrient broth.

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