Chemoenzymatic Synthesis of (R)- and (S)-4-Amino-3-Methylbutanoic Acids
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 20 (1) , 159-166
- https://doi.org/10.1080/00397919008054627
Abstract
(R)- and (S)-4-Amino-3-methylbutanoic acids were synthesized in high yields via initial enantioselective hydrolysis of dimethyl 3-methylglutarate to methyl (R)-3-methylglutarate with pig liver esterase. The ester group was converted to an amine to give (R)-4-amino-3-methylbutanoic acid; the carboxylic acid was converted to an amine to give (S)-4-amino-3-methylbutanoic acid.Keywords
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