Formation of the triple-stranded polynucleotide helix, poly(A.A.U).
- 1 August 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (15) , 5120-5124
- https://doi.org/10.1073/pnas.84.15.5120
Abstract
A polynucleotide helical structure containing two strands of poly(A) and one of poly(U) is reported. As shown by spectroscopic observations, the complex only forms when the poly(A) strands are of Mr between 9000 and 50,000 (degree of polymerization .simeq.28-150), whereas the size of the poly(U) strand has no effect. This limitation may explain why poly(A .times. A .cntdot. U) was not seen in previous investigations. The potential of the poly(A) tails of MRNA for formation of this triple helix and of A .cntdot. A .cntdot. U or/and A .cntdot. A .cntdot. T triplet formation to contribute to the binding of specific RNA strands to geneencoding nucleic acid double helicies are noted.This publication has 17 references indexed in Scilit:
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