Recovery of Locomotion following Transplantation of Monoaminergic Neurons in the Spinal Cord of Paraplegic Ratsa
- 1 November 1998
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 860 (1) , 393-411
- https://doi.org/10.1111/j.1749-6632.1998.tb09064.x
Abstract
Severe traumatic lesions of the spinal cord yield a permanent deficit of motricity in adult mammals and specifically a loss of locomotor activity of hindlimbs when the lesion is located at the lower thoracic level. To restore this function, we have developed a paradigm of transplantation in rats based on a transection model of the spinal cord and the subsequent injection at the sublesional level of a suspension of embryonic brainstem monoaminergic neurons which play a key role in the modulation of locomotion. A genuine locomotion was characterized in transplanted animals by electromyographic and electroneurographic recordings. This correlated with a specific reinnervation pattern of targets, where typical synapses were found, and with the normalization of biochemical parameters.Keywords
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