THE THERAPEUTIC INDEX OF CHEMOTHERAPEUTIC AGENTS: THE EFFECT OF NUCLEIC ACID ON DIMIDIUM BROMIDE

Open Access

1 December 1955

journal article
Published by Wiley in Journal of Applied Bacteriology

Vol. 18 (3) , 397-400
https://doi.org/10.1111/j.1365-2672.1955.tb02095.x

Abstract

SUMMARY: The complexes of dimidium bromide with nucleic acids are less toxic and bactericidal than dimidium bromide itself, but the toxicity is reduced more than the antibacterial activity. The therapeutic activity is, therefore, raised.

Keywords

BACTERICIDAL
ANTIBACTERIAL
SUMMARY
TOXICITY
CHEMOTHERAPEUTIC AGENTS
THERAPEUTIC INDEX
INDEX OF CHEMOTHERAPEUTIC
NUCLEIC
DIMIDIUM

This publication has 3 references indexed in Scilit:

THE ANTIBACTERIAL ACTIVITY OF PHENANTHRIDINE COMPOUNDS
British Journal of Pharmacology and Chemotherapy, 1954
THE CHEMOTHERAPEUTIC ACTION OF PHENANTHRIDINE COMPOUNDS
British Journal of Pharmacology and Chemotherapy, 1950
“ANTRYCIDE”*—A NEW TRYPANOCIDAL DRUG
British Journal of Pharmacology and Chemotherapy, 1950