Intravenous Administration of the Photoactivatable Dye Pheophorbide-a to Dogs -with Reference to Tissue Uptake and Distribution of the Dye-
Open Access
- 1 January 1988
- journal article
- Published by Japan Society for Laser Surgery and Medicine in THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE
- Vol. 9 (3) , 327-330
- https://doi.org/10.2530/jslsm1980.9.3_327
Abstract
Pheophorbide-a (PpA) has been appreciated as a new photosensitizer for photodynamic therapy by radiation of Nd-YAG laser with less adverse effects, especially photosensitive dermatitis. Lineal relation was proved between the concentration of PpA and emission fluorescence (670nm) using 410nm excitation. Tissue concentrations of PpA were caluculated following intravenous administrations of the dye (3mg/kg body weight) in dogs. Maximum uptake in canine tissues was achieved 1-3 hrs after the dye administration with rapid decline within 24hrs. PpA was distributed in the lung, liver and spleen, and excreted mainly into the bile.Keywords
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