A SOLID-PHASE METHOD FOR DNA SEQUENCING

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 9  (12) , 1634-1637
Abstract
A solid-phase method for DNA sequencing was developed which involves immobilization of the terminally labeled DNA fragment on DEAE-paper followed by chemical modification and cleavage at G, A + G, C + T, and C sites. The new technique is more rapid, less laborious and has the same efficiency as the Maxam and Gilbert method.

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