The Antiheparin Effect of α1-Acid Glycoprotein and Platelet Material, Evaluated by the Heparin Thrombin Clotting Time
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 6 (6) , 339-346
- https://doi.org/10.1159/000214200
Abstract
The effect on the heparin thrombin clotting time (HTCT) of a so-called acute phase protein, α1-acid glycoprotein, was studied in test systems consisting of purified fibrinogen, antithrombin III, heparin and thrombin, and compared to the effect of platelet material (crude platelet factor 4). In these test systems a physiological concentration of α1-acid glycoprotein (1 g/l) inhibited heparin more effectively than did soluble platelet material from 200 × 109 platelets/1. The present observations suggest that α1-acid glycoprotein is of great significance for the so-called heparin tolerance, whereas platelet material proved less important.Keywords
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