PRESERVATION OF CANINE HEARTS AFTER WARM ISCHEMIA (ZERO TO 30 MINUTES) AND ONE TO 2 DAYS OF HYPOTHERMIC STORAGE - COMPARATIVE ANALYSIS OF CRYSTALLOID AND COLLOID SOLUTIONS WITH DIFFERENT OSMOLARITY AND ION COMPOSITION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 74  (4) , 594-603
Abstract
The effect of extracellular crystalloid (Ringer''s) and colloid (silica gel fraction [SGF]) solutions, and intracellular crystalloid (Sacks) and colloid (modified silica gel fraction [MSGF]) solutions for canine (dog) heart preservation in a 24-48 h model of hypothermic storage and 0-30 min of warm ischemia was compared. Canine hearts flushed with an intracellular colloid solution (MSGF) had better survival rates after transplantation than did the hearts flushed with intracellular crystalloid solutions (Sacks). Better survival results were observed in the group of hearts flushed with extracellular colloid (SGF) solutions than extracellular crystalloid (Ringer''s) solutions. The most important theoretical factor in heart preservation appears to be hyperosmolarity and elevated concentration of K, proteins and glucose.

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