SHORT AND LONG TERM EFFECTS OF METHYL- AND ETHYLNITROSOUREA (MNU & ENU) ON THE DEVELOPING NERVOUS SYSTEM OF THE RAT

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Abstract
Single injections of ENU to WAG rats were given in the perinatal period and repeated injections of MNU to adult WAG rats. In tables illustrating the various experiments, the occurrence of tumors was given for each animal. The tumors were classified according to their sites. For brain tumors a subdivision was made between those macroscopically visible and those discovered by microscopy. The ratio between neural and extraneural tumors in perinatally exposed animals is rather constant (about 90 and 10%, respectively). In experiments in young adult rats neural tumors still predominated but extraneural ones rose to about 40%. The incidence of neural tumors was impressively high in perinatal induction experiments (> 95%). Almost all CNS tumors showed the characteristics of oligodendrogliomas; highly differentiated in smaller tumors and more anaplastic with regressive changes in larger ones.