YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621
- 1 January 2004
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 57 (6) , 379-382
- https://doi.org/10.7164/antibiotics.57.379
Abstract
Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2-16μg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4μg/ml.Keywords
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