Fenfluramine Hydrochloride Treatment of Parkinsonism
- 1 April 1977
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 34 (4) , 255-256
- https://doi.org/10.1001/archneur.1977.00500160069016
Abstract
• The oral administration of fenfluramine hydrochloride, which acts centrally to augment serotonin-mediated synaptic function, did not alter extrapyramidal signs in either untreated or levodopatreated parkinsonian patients. These results support the contention that biochemical indices of serotonergic dysfunction in Parkinson disease do not reflect a critical role for serotonin-containing neural systems in the pathophysiology of parkinsonism and that serotonin-active drugs afford no significant therapeutic benefit to patients with this disorder.This publication has 1 reference indexed in Scilit:
- Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexiaJournal of Pharmacy and Pharmacology, 1973