DNA synthesis control in yeast: An evolutionarily conserved mechanism for regulating DNA synthesis genes?
- 1 December 1992
- Vol. 14 (12) , 823-830
- https://doi.org/10.1002/bies.950141206
Abstract
After yeast cells commit to the cell cycle in a process called START, genes required for DNA synthesis are expressed in late G1. Periodicity is mediated by a hexameric sequence, known as a MCB element, present in all DNA synthesis gene promoters. A complex that specifically binds MCBs has been identified. One polypeptide in the MCB complex is Swi6, a transcription factor that together with Swi4 also binds G1 cyclin promoters and participates in a positive feedback loop at START. The finding that Swi6 is directly involved in both START and DNA synthesis gene control suggest a model in which Swi6, activated through its participation in START, serves as the central transcription factor in coordinating late G1 gene expression. The mechanism may be conserved in all eukaryotic cells.Keywords
This publication has 46 references indexed in Scilit:
- A central role for SWI6 in modulating cell cycle Start-specific transcription in yeastNature, 1992
- SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeastNature, 1992
- Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdclO+Nature, 1992
- Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast.Genes & Development, 1991
- Rel-Associated pp40: an Inhibitor of the Rel Family of Transcription FactorsScience, 1991
- Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcriptionCell, 1991
- Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsalCell, 1990
- Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activationCell, 1990
- Periodic events in the cell cycleCurrent Opinion in Cell Biology, 1990
- A phage repressor–operator complex at 7 Å resolutionNature, 1985