An Elevation of Plasma TSH Concentration in Spontaneously Hypertensive Rats (SHR)
- 1 July 1975
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 149 (3) , 661-663
- https://doi.org/10.3181/00379727-149-38874
Abstract
Summary Thyroid activity was tested in two substrains of SHR. Plasma level and pituitary content of TSH increased significantly in both substrains of SHR. As a result, the thyroid weight and thyroidal radioiodine uptake increased significantly. Plasma T3 concentration was decreased in Kyoto sub-strain but was normal in NN substrain, while plasma T4 concentration decreased significantly in both substrains. Since the pituitary content and plasma level of TSH were significantly higher in spite of the normal concentration of plasma T3, it is concluded that the pituitary “hormostat” is set at a higher level at least in the NN substrain of SHR.Keywords
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