TRIM5α selectively binds a restriction-sensitive retroviral capsid
Open Access
- 20 June 2005
- journal article
- Published by Springer Nature in Retrovirology
- Vol. 2 (1) , 40
- https://doi.org/10.1186/1742-4690-2-40
Abstract
TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the alpha-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5alpha binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.Keywords
This publication has 21 references indexed in Scilit:
- Disruption of Human TRIM5α Antiviral Activity by Nonhuman Primate OrthologuesJournal of Virology, 2005
- Retrovirus Restriction by TRIM5α Variants from Old World and New World PrimatesJournal of Virology, 2005
- Species-Specific Variation in the B30.2(SPRY) Domain of TRIM5α Determines the Potency of Human Immunodeficiency Virus RestrictionJournal of Virology, 2005
- A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 RestrictionCurrent Biology, 2005
- Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1Nature, 2004
- The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeysNature, 2004
- Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factorsNature Medicine, 2003
- Abrogation of Ref1 Retrovirus Restriction in Human CellsJournal of Virology, 2002
- SPRY domains in ryanodine receptors (Ca2+-release channels)Trends in Biochemical Sciences, 1997
- A nucleoprotein complex mediates the integration of retroviral DNA.Genes & Development, 1989