Mitochondrial DNA and aging
- 24 September 2004
- journal article
- review article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 107 (4) , 355-364
- https://doi.org/10.1042/cs20040148
Abstract
Among the numerous theories that explain the process of aging, the mitochondrial theory of aging has received the most attention. This theory states that electrons leaking from the ETC (electron transfer chain) reduce molecular oxygen to form O2*- (superoxide anion radicals). O2*-, through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA), thus increasing further the production of ROS. Ultimately, this 'vicious cycle' leads to a physiological decline in function, or aging. This review focuses on recent developments in aging research related to the role played by mtDNA. Both supportive and contradictory evidence is discussed.Keywords
This publication has 108 references indexed in Scilit:
- Experimental evidence against the mitochondrial theory of aging A study of isolated human skeletal muscle mitochondriaExperimental Gerontology, 2003
- Evolution and genetic structure of the great tit (Parus major) complexProceedings Of The Royal Society B-Biological Sciences, 2003
- Targeting human 8‐oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione‐induced oxidative stressGlia, 2003
- The mitochondrial theory of aging: dead or alive?Aging Cell, 2003
- Repair of mitochondrial DNA damage induced by bleomycin in human cellsMutation Research/DNA Repair, 1995
- Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cellsCarcinogenesis: Integrative Cancer Research, 1993
- Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragmBiochemical and Biophysical Research Communications, 1991
- Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic NeuropathyScience, 1988
- Strand breaks of mammalian mitochondrial DNA induced by carcinogensChemico-Biological Interactions, 1977
- Aging: A Theory Based on Free Radical and Radiation ChemistryJournal of Gerontology, 1956