PARA-AMINOSALICYLIC ACID TREATMENT OF TUBERCULOSIS - A REVIEW

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Abstract
The use of p-aminosalicylic acid (PAS) in treating tuberculosis is reviewed. Both in vitro and in vivo laboratory tests, as well as extensive clinical investigations, indicate that PAS is valuable for the treatment of tuberculosis. Most prepns. of PAS are insufficiently pure. Elimination of the nauseous and noxious contaminants and degradation products might obviate many of the present difficulties in administering the large dosage of PAS that is essential to its successful use. Combination of PAS with intermittent treatment with streptomycin greatly increases the applicability and effectiveness of chemotherapy in tuberculosis.