The outcome of IVF-embryo transfer treatment in patients who develop three follicles or less

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Abstract
Among 828 patients undergoing IVF–embryo transfer treatment, the implantation and pregnancy rates of patients who developed ≤3 follicles were compared prospectively with those patients who had a normal response. Patients who developed 1 to 3 follicles during ovarian stimulation elected to proceed with oocyte collection, have intrauterine insemination if appropriate, or to have their cycle cancelled. In the group of patients who developed ≤3 follicles and who were aged 3 follicles. However, in patients aged >40 years who developed ≤3 follicles, a moderate, albeit non-significant decrease in implantation rate (3.8 versus 7.8%; OR = 1.91; CI = 0.4–57.0) and pregnancy rate (4.2 versus 18.3%; OR = 1.92; CI = 0.38–57.0) was observed when compared with patients of a similar age who developed >3 follicles. Patients aged <40 years, unlike older patients, maintain good implantation and pregnancy rates despite a poor response to ovarian stimulation. This study indicates that for this group of women, continuation of IVF treatment is a better option than cancellation.

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