Factors Regulating Thymidine Kinase in Regenerating Liver

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Abstract
Thymidine kinase [EC 2.7.1 21] activity was measured during the course of liver regeneration in order to find out the trigger for DNA replication. Actinomycin D did not affect the enzyme activity but cycloheximide greatly decreased the activation of thymidine kinase 20–26 hr after the partial hepatectomy. In addition, the lack of growth hormone resulted in the retardation of hepatic regeneration. Therefore, an accumulation of messenger RNA for thymidine kinase seemed to be necessary before an abrupt rise in this enzyme. Cyclic AMP suppressed in vitro the activity of the enzyme prepared from hypophysectomized rats.

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