Increase by ?-adrenolytic drugs of acetylcholine release evoked by field stimulation of the guinea-pig ileum

1 January 1979

journal article
research article
Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie

Vol. 309 (3) , 255-257
https://doi.org/10.1007/bf00504758

Abstract

The release of acetylcholine evoked by field stimulation of the guinea-pig ileum (3 Hz) is increased by yohimbine and tolazoline but not affected by phentolamine. It is proposed that yohimbine and tolazoline by blocking α-adrenoceptors of the cholinergic nerves abolish the inhibition caused by endogenous noradrenaline, and thus facilitate the output of acetylcholine.

Keywords

This publication has 9 references indexed in Scilit:

PHARMACOLOGICAL CHARACTERIZATION OF THE PRESYNAPTIC α-ADRENOCEPTORS REGULATING CHOLINERGIC ACTIVITY IN THE GUINEA-PIG ILEUM
British Journal of Pharmacology, 1978
Differentiation between pre‐ and postjunctional α‐receptors in guinea pig ileum and rabbit aorta
Acta Physiologica Scandinavica, 1978
A comparison of pre- and postsynaptic effects of α-adrenolytic drugs in the pulmonary artery of the rabbit
Neuroscience, 1977
Formation and release of acetylpyrrolidinecholine (N-methyl, N-acetoxyethylpyrrolidinium) as a false cholinergic transmitter in the myenteric plexus of the guinea-pig small intestine
Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
THE EFFECTS OF MORPHINE ON THE RELEASE OF NORADRENALINE FROM THE CAT ISOLATED NICTITATING MEMBRANE AND THE GUINEA‐PIG ILEUM MYENTERIC PLEXUS‐LONGITUDINAL MUSCLE PREPARATION
British Journal of Pharmacology, 1975
GAS CHROMATOGRAPHIC ESTIMATION OF ACETYLCHOLINE IN THE RABBIT HEART USING A NITROGEN SELECTIVE DETECTOR
Journal of Neurochemistry, 1973
The effects of sympathetic nerve stimulation and guanethidine on parasympathetic neuroeffector transmission; the inhibition of acetylcholine release
Journal of Pharmacy and Pharmacology, 1971
The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip
British Journal of Pharmacology, 1969
THE PHARMACOLOGY OF BENZYL-IMIDAZOLINE (PRISCOL)
1947