CALCIFICATION AND ITS INHIBITION IN COCCOLITHOPHORIDS1,2

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Abstract
SUMMARY: The protein synthesis inhibitors cycloheximide and chloramphenicol and the transport inhibitors LaCl3, oligoniycin, and ethacrynic acid were found to inhibit reversibly calcium uptake, coccolith formation, and cell division in the coccolithophorid Cricosphacra (Hymenomonas) carterae. With some, compounds, recovery of calcification was retarded, and in the case of oligomycin, incomplete. Glycerol, 0.5 M, partially reversed the inhibitory effect of chloramphenicol on calcification but not on division. Ouabain was without significant effect on calcium uptake but slowed division in 3 of 5 experiments. Ruthenium red inhibited, neither calcification nor division. In the absence of light, calcification did not occur.