Dense bodies and langerhans granules after application of podophyllum resin
- 1 January 1975
- journal article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 253 (3) , 277-285
- https://doi.org/10.1007/bf00561153
Abstract
The application of an alcoholic solution of podophyllum resin at concentrations above 10% for seven hours on guinea-pig udders increases the number of dense intracytoplasmic bodies in the Langerhans cells localized in the epidermis. A close relationship can be established between these inclusions and the typical Langerhans granules in view of the numerous intermediate forms with features of one or the other. Serial sections of these structures confirm the irregularity not only of the lysosome-like bodies but also of the Langerhans granules, which may be fusiform or oblong or even present two vesicular dilatations, one at each end of the rod. Durch die Anwendung von Podophyllin in alkoholischer Lösung bei Konzentrationen über 10% für 7 Stunden am Euter des Meerschweinchens konnte eine Zunahme von elektronendichten intracytoplasmatischen Körperchen in Langerhanszellen innerhalb der Epidermis ausgelöst werden. Eine sehr enge Beziehung zwischen diesen Einschlüssen und dem typischen Langerhans-Granula konnte durch die Beobachtung zahlreicher Intermediärformen mit Zügen der einen oder anderen Organelle festgestellt werden. Serienschnitte dieser Strukturen bestätigten die Irregularität nicht nur der lysomenartigen Körperchen, sondern auch der Langerhans-Granula, welche fusiform oder länglich sein können oder aber zwei vesiculäre Erweiterungen besitzen können, jede auf einem Ende der stabförmigen Organelle.Keywords
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