Effect of Dietary Butylated Hydroxytoluene (BHT) on the Activity of a Chicken Liver Enzyme That Metabolizes Foreign Compounds

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Abstract
Activity of the liver enzyme O-demethylase, which activated and inactivated certain drugs and chemicals, was increased to 177% of control levels in adult female White Leghorn chickens after 15 days on a diet containing 1% butylated hydroxytoluene (BHT). This compared with the 177% activity level of this enzyme in adult male mice (fed the chicken diet) at 3 days. Reducing dietary protein levels from 17.5 to 9.5% in the absence of the antioxidant did not alter O-demethylase activity in the livers of mice or chickens.

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