An HPLC Method for the Simultaneous Quantitation of Quinidine, Procainamide, N-Acetylprocainamide, and Disopyramide

Abstract
A high performance liquid chromatographic method is reported, which incorporates three internal standards (I-cinchonidine, N-propylprocainamide, and para-chlorodisopyramide) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: quinidine, procainamide, N-acetylprocainamide, and disopyramide. Compounds were separated using combined ion-pairing and adsorption chromatography on a silica column. inter-run variation was 5.9 CV% for all drugs.

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