Left atrial myxoma. A morphologic and histogenetic study.

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Abstract
Seven cases of excised left atrial myxoma are described. These are compared with organizing and organized thrombi. The tumors occurred at ages ranged from 13-48 yr with male preponderance. There were distinct histological and histochemical differences between myxomas and thrombi. Myxomas were lobulated, soft and gelatinous. The cells were arranged singly, in syncytium or in gland like manner and around blood vessels. Scant to abundant acid mucopolysaccharide rich stroma with strong metachromasia was present. The cells on histochemical staining revealed a wide range of differentiation and contained small amounts of neutral mucopolysaccharides. Thrombi were firm and laminated with cells, arranged in several stratified layers. Metachromasia was absent. Neutral polysaccharides were absent within the cells of thrombi. Cardiac myxoma is evidently a neoplasm possibly arising from multipotential mesenchymal cells.