A Double-Blind Clinical Trial of a New Benzodiazepine, Flunitrazepam, as a Hypnotic Agent

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Abstract
Flunitrazepam 3 mg and 5 mg, phenobarbitone 200 mg and placebo were compared as pre-operative hypnotic agents in a double-blind trial. Two hundred and seventy-three patients were included in the study. The lower dose 3 mg of flunitrazepam was shown to be superior to the higher dose 5 mg and to phenobarbitone 200 mg and placebo.