Observations on the Distribution and Action of Substance P in Marine Animals1

Abstract
Various parts of the CNS of the dogfish and the ray were found to contain large amounts of Substance P (SP), up to 50 units/g fresh organ. It was also found in extracts of intestine of these species, and in minute amounts in the hagfish (Myxine). No SP activity was found in total extracts of Mytilus and Actiniaria, but small amounts were found in Ciona. The strongly stimulating action of SP on teleost intestine was confirmed with superfusion technique.

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