11β-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte

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Abstract
The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) catalyses the conversion of physiological glucocorticoids to inactive products, thus modifying the access of glucocorticoids to glucocorticoid and mineralocorticoid receptors. Glucocorticoids may affect ovarian function both indirectly and via binding to ovarian receptors. We have demonstrated 11β-HSD bioactivity and mRNA expression in rat ovary in vitro. The enzyme was localized to oocytes and luteal bodies immunohistochemically using two antibodies raised against purified rat liver 11β-HSD. These data are supported by in-situ hybridization studies, which also localized 11β-HSD mRNA expression to oocytes and luteal bodies. The results suggest that 11β-HSD may modulate the effects of glucocorticoid on ovarian function. Journal of Endocrinology (1992) 135, 53–58

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