Natural Behavior Polymorphism Due to a cGMP-Dependent Protein Kinase of Drosophila
- 8 August 1997
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 277 (5327) , 834-836
- https://doi.org/10.1126/science.277.5327.834
Abstract
Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)–dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism.Keywords
This publication has 30 references indexed in Scilit:
- Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase IIScience, 1996
- Induction of a dominant negative CREB transgene specifically blocks long-term memory in DrosophilaCell, 1994
- Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant MiceScience, 1992
- cAMP-dependent protein kinase and the disruption of learning in transgenic fliesNeuron, 1991
- cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neuronesNature, 1986
- Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki diseaseNature, 1986
- Intracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortexBrain Research, 1986
- A transposable element inserted just 5′ to a Drosophila glue protein gene alters gene expression and chromatin structureCell, 1983
- Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogasterNature, 1981
- Foraging strategies ofDrosophila melanogaster: A chromosomal analysisBehavior Genetics, 1980