Central catecholamine and peripheral noradrenaline depletion by 6-hydroxydopamine and active avoidance learning in rats.

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Abstract
The relation among catecholamine (CA) depletion, plasma corticosterone (11-OHCS) levels and active aversive learning was studied. A baseline study showed no significant relation between resting levels of 11-OHCS and central and/or peripheral CA depletion. On a two-way avoidance learning task, depletion of brain CA produced a widespread learning deficit. When both central and peripheral CA were depleted, only escape learning emerged. Similar effects occurred on a one-way task, but differences were not so marked. The findings are discussed in terms of a theory of CA-dependent cues.