Cumulative Failure Rate of Ileal Pouch-Anal Anastomosis and Quality of Life After Failure

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Abstract
Up of 21 patients, the successful group, and the healthy population. METHODS: Data were collected from patient histories, with the probability of pouch failure being calculated by the Kaplan-Meier method. Patients with pouch failure and controls were sent a Short-Form 36-item quality-of-life questionnaire, and data were analyzed with pairedt-test. RESULTS: The overall failure rate was 5.3 percent (26), including 24 pouch excisions and 2 early deaths (0.4 percent). Cumulative probabilities of pouch failure were 1, 5, and 7 percent at 1, 5, and 10 years, respectively. Neither pouchitis, gender, nor diagnosis correlated with pouch failure, but fistula formation (P< 0.001) did. Patients with failure had lower quality-of-life scores for physical function (P< 0.02), social function (P< 0.04), energy (P< 0.02), and physical role function (P< 0.03) than the healthy population. Scores for physical function (P< 0.01), energy (P< 0.01), and physical role function (P< 0.05) were also lower than those of control patients. CONCLUSIONS: The most common cause of pouch failure is fistula, whereas pouch excision is rarely caused by pouchitis. The impaired quality of life of patients in the failure group was caused by impairment of physical function and restrictions in social life. © The ASCRS 2002...