An Expeditious Synthesis of Pyrophosphate Analogues of Farnesyl Pyrophosphate Using the Phosphonylating Agent Methyl Methylphosphonomorpholidate
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (09) , 663-664
- https://doi.org/10.1055/s-1991-20834
Abstract
Reaction of methyl lithiomethylphosphonomorpholidate with farnesyl chloride (1-chloro-3,7,11-trimethyl-2,6,10-dodecatriene) followed by demethylation and subsequent coupling with phosphoric acid or methylphosphonic acid gave O-(farnesylmethylphosphono)phosphate (8; farnesylmethylphosphonic phosphoric anhydride) and O-(farnesylmethylphosphono)methylphosphonate (9; farnesylmethylphosphonic methylphosphonic anhydride), respectively. Furthermore, conversion of title compound 2 into tetrabutylammonium methylphosphonomorpholidate (10) followed by coupling with farnesylphosphonic acid gave O-(farnesylphosphono)methylphosphonate (12; farnesylphosphonic methylphosphonic anhydride).Keywords
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