Inhibitory effect of lysophosphatidylcholine on the histamine release from rat peritoneal mast cells
- 1 April 1985
- journal article
- mechanisms of-histamine-release
- Published by Springer Nature in Inflammation Research
- Vol. 16 (3-4) , 113-117
- https://doi.org/10.1007/bf01983115
Abstract
Histamine release from isolated rat peritoneal mast cells induced by compound 48/80 (0.5 μg/ml) or antigen-antibody reaction was inhibited by lysophosphatidylcholine in a dose-dependent fashion at concentrations up to 4 μM. Within the same range of concentration, lysophosphatidylcholine exhibited a membrane-stabilizing action on the model membrane systems decreasing the permeability of lipid bilayer and the fluidity of liposomal membrane in the liquid crystalline state. At concentrations higher than 8 μM, lysophosphatidylcholine damaged the cell membrane and subsequently histamine was released. It was assumed that lysophosphatidylcholine may act as an endogenous membrane stabilizer inhibiting histamine release in normal mast cells.Keywords
This publication has 16 references indexed in Scilit:
- Effect of N-methylation of phosphatidylethanolamine on the fluidity of phospholipid bilayersBiochemical and Biophysical Research Communications, 1984
- Histamine release inhibition and prevention of the decrease in membrane fluidity induced by certain anti-allergic drugs: Analysis of the inhibitory mechanisms of NCO-650Inflammation Research, 1983
- Rat mast cell phospholipase A2: activity toward exogenous phosphatidylserine and inhibition by N-(7-nitro-2,1,3-benzoxadiazol-4-yl)phosphatidylserineBiochemistry, 1982
- Phospholipid Methylation and Biological Signal TransmissionScience, 1980
- Histamine release from rat peritoneal mast cells by phospholipase A. The “activation” of phospholipase a by phospholipidsBiochemical Pharmacology, 1978
- Interaction of spin-labeled lysophosphatidylcholine with rabbit erythrocytesBiochemistry, 1978
- Fluorescent probes in model membranes I: anthroyl fatty acid derivatives in monolayers and liposomes of dipalmitoylphosphatidylcholineBiochemistry, 1977
- Composition of phospholipids and phospholipid fatty acids in RAT mast cellsMolecular and Cellular Biochemistry, 1976
- Phosphatidase A activity of isolated rat mast cells and of red blood cells, white blood cells and spinal ganglion cellsExperimental Cell Research, 1965
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959