Fragile (X) expression, age and the degree of intellectual handicap in the male

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Abstract
The proportion of cells expressing the fra(X) was compared to the guardian's opinion of who was the “brighter” in 31 sibships of 2 or more affected males. Six fra(X) positive males in the normal workforce were compared in a similar way to other affected relatives. A correlation was found between lower values of expression and “brightness” by the Wilcoxson signed rank test (<0.01, 2-tail). A decline in fra(X) expression occurs with age. Some apparently normal non-expressing transmitting males may be accounted for by these findings.