Hepatic Granulomas and Other Hepatic Lesions Associated with BCG Immunotherapy for Cancer

1 June 1974

journal article
research article
Published by Oxford University Press (OUP) in American Journal of Clinical Pathology

Vol. 61 (6) , 747-752
https://doi.org/10.1093/ajcp/61.6.747

Abstract

Twelve of 21 patients treated with BCG immunotherapy developed hepatic abnormalities. Percutaneous liver biopsy was performed in all twelve. A diffuse noncaseating granulomatous reaction with fatty metamorphosis and minute hepatic parenchymal necrosis was demonstrated in six. The development of hepatic granulomas appeared to be unrelated to total amount of BCG administered, duration of therapy, or immunologic status of the patients.

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