Acetylcholine receptor antibodies in infants of mothers with myasthenia gravis

Abstract
Antiacetylcholine receptor (AChR) antibodies were studied in 3 infants of mothers with generalized myasthenia gravis, using immunoprecipitation and concanavalin A Sepharose assays. Abnormal titers of anti-AChR antibodies were found in all 3 infants, but only 1 had symptoms of neonatal myasthenia gravis. The factor inducing transient neonatal myasthenia gravis may depend on the maternal level of anti-AChR antibody.