Levamisole and the Immune Response

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Abstract
To the Editor: In "Levamisole and Cell-Mediated Immunity",1 an editorial on the report by Tripodi et al. entitled "Drug-Induced Restoration of Cutaneous Delayed Hypersensitivity in Anergic Patients with Cancer,"2 Churchill and David suggest that the absence of skin reactivity in these patients might be due to an insufficient number of lymphocytes, a defective production of lymphocyte mediators, changes in vascular permeability, an abnormal macrophage function or the presence of serum inhibitors.We have investigated several of these hypotheses. Skin reactivity (Table 1 ). After treatment with 150 mg of levamisole per day for three consecutive days reactivity to 10IU of purified . . .