Some studies on the hepatic microsomal enzyme activities and steroid hormone levels in carp, Cyprinm carpio exposed for six months

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Abstract
A short‐term study from October 1975 to April 1976 was carried out by keeping 10 carp in two separate cages (five in each) at each of the three sites, namely, Wraysbury Reservoir, Ryemeads Sewage Lagoon and Deephams Sewage Lagoon (Fish unit). Fish were not artificially fed. Blood samples were collected at monthly intervals. Activities of the following hepatic microsomal enzymes, aminopyrine demethylase, p‐nitro‐reductase, UDP‐glucurony! transferase and 1‐leucyl‐p‐naphthylamide splitting enzymes were measured; cytochrome P450 and microsomal protein contents were also estimated.The levels of androgens, oestrogens and corticoid hormones were measured in the circulating blood at monthly intervals. Results indicated that there was (a) no significant increase in the activities of all the enzymes measured except for an increase in cytochrome P450 in the fish kept at Deephams Sewage treatment works, (b) no significant increase in microsomal protein content at the three sites and (c) no significant changes in the levels of plasma androgens, oestrogens and corticoids of the circulating blood.